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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 10 μL x 10 mM (in DMSO)
  • 20 μL x 10 mM (in DMSO)
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
Apoptosis
Autophagy
GABA Receptor
iGluR
Endogenous Metabolite
GluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
NMDAR
Beta Amyloid
PDE
ROS
Monoamine Oxidase
Antibacterial
COX
NF-κB
MAO
Serotonin Transporter
Potassium Channel
JNK
Reactive Oxygen Species
Parasite
Calcium Channel
PPAR
Gamma-secretase
Caspase
GSK-3
Norepinephrine
Sodium Channel
Cytochromes P450
Adenosine Receptor
TNF
Akt
ERK
Influenza Virus
Nrf2
HIV Protease
Interleukin
PI3K
CDK
CaMK
LRRK2
NO Synthase
p38 MAPK
Ferroptosis
Mitophagy
Beta-Secretase
BACE
Antifungal
Transferase
Drug Metabolite
Mitochondrial Metabolism
MMP
DNA/RNA Synthesis
Antibiotic
Virus Protease
Wnt/beta-catenin
Sigma receptor
Cannabinoid Receptor
Adenylate cyclase
mTOR
Phosphatase
P-gp
Dehydrogenase
TRP/TRPV Channel
Bcl-2 Family
SARS-CoV
IκB/IKK
Src
VEGFR
IL Receptor
Estrogen/progestogen Receptor
Bcr-Abl
PKC
Microtubule Associated
AMPK
Phospholipase
Imidazoline Receptor
Trk receptor
MEK
PARP
P2X Receptor
GlyT
Glucosidase
Antioxidant
Sirtuin
HDAC
Melatonin Receptor
FLT
Anti-infection
c-Kit
NOD-like Receptor (NLR)
Lipoxygenase
EGFR
MRP
OX Receptor
PKA
JAK
Epigenetic Reader Domain
CCR
glycosidase
TLR
Tyrosinase
Amino Acids and Derivatives
HIF/HIF Prolyl-Hydroxylase
MT Receptor
NOD
Histone Methyltransferase
LPL Receptor
Estrogen Receptor/ERR
ABC Transporter
FAAH
Prostaglandin Receptor
P2Y Receptor
MAPK
Ras
S1P Receptor
STAT
GPCR
MDM-2/p53
UGT
Aurora Kinase
FGFR
HMG-CoA Reductase
RAAS
AAK1
TGF-beta/Smad
Neurokinin receptor
Carbonic Anhydrase
Histone Demethylase
HSV
IGF-1R
NOS
PTEN
Retinoid Receptor
ROR
IFNAR
NADPH
Glucocorticoid Receptor
AAK1 (AP2 associated kinase 1)
Antiviral
transporter
S6 Kinase
c-Met/HGFR
Rho
Histone Acetyltransferase
IRAK
PGE Synthase
Integrin
HSP
PERK
HBV
Monoamine Transporter
Casein Kinase
Chloride channel
FXR
Aryl Hydrocarbon Receptor
Epoxide Hydrolase
p53
Angiotensin-converting Enzyme (ACE)
c-Fms
Advanced Glycation End Products
Necroptosis
OCT
Raf
GRK
Stearoyl-CoA Desaturase (SCD)
DYRK
Progesterone Receptor
Liver X Receptor
Reverse Transcriptase
Gap Junction Protein
Transaminase
MIF
Antifection
FAK
CSF-1R
Acyltransferase
Decarboxylase
ATM/ATR
FOXO
ATPase
Nucleoside Antimetabolite/Analog
IAP
PDGFR
CRISPR/Cas9
Hydroxylase
CFTR
Monocarboxylate transporter
Serine/threonin kinase
Cysteine Protease
Topoisomerase
Guanylate cyclase
OXPHOS
STING
Free radical scavengers
CGRP Receptor
Immunology/Inflammation related
PAFR
DUB
RSV
FOXO3
Hck
ROCK
RANKL/RANK
IDO
Annexin A
Neuropeptide Y Receptor
Bombesin Receptor
Telomerase
SGLT
Lipid
PSMA
PDK
SGK
DNA Methyltransferase
Thrombin
CAT
Na+/Ca2+ Exchanger
GTPase
c-Myc
CaSR
HCN Channel
PAK
PAI-1
ALK
GST
Carboxypeptidase
Aromatase
HIF
REV-ERB
ROS Kinase
Glutaminyl Cyclase
Neurotensin Receptor
Glutaminase
RIP kinase
Somatostatin
PAD
Androgen Receptor
Indoleamine 2,3-Dioxygenase (IDO)
Survivin
Aquaporin
Cuproptosis
Thyroid hormone receptor(THR)
Proteasome
Taste receptor
NPC1L1
Reductase
LDLR
DNA Alkylation
Neprilysin
Adenosine Deaminase
Liposome
NR4A
E1/E2/E3 Enzyme
Adiponectin Receptor
ATP Citrate Lyase
RAR/RXR
HCV Protease
Arrestin
Glutathione Peroxidase
Prolyl Endopeptidase (PREP)
LDL
Cadherin
GluCls
Pyroptosis
FKBP
MLK
Lipase
Serine Protease
Hexokinase
Chk
Orphan Receptor
MNK
OAT
Syk
NMU2R
BTK
Vitamin
NMUR

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