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(1R,2R)-2-PCCA hydrochloride

(1R,2R)-2-PCCA hydrochloride
(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Catalog No. T13423Cas No. 1609563-71-4
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Purity:99.88%
ee:99.92%
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(1R,2R)-2-PCCA hydrochloride

Purity: 99.88%
Catalog No. T13423Alias (1R,2R)-2-PCCA(hydrochloride)Cas No. 1609563-71-4

(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$98In Stock
5 mg$147In Stock
10 mg$289In Stock
25 mg$596In Stock
50 mg$787In Stock
100 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$169In Stock
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Product Introduction

Bioactivity
Description
(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Targets&IC50
GPR88-22F cells:603 nM (EC50), GPR88 receptor:56 nM (EC50, HEK293 cell), GPR88 receptor:3 nM (EC50, cell-free assay)
In vitro
(1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1].
Alias(1R,2R)-2-PCCA(hydrochloride)
Chemical Properties
Molecular Weight528.56
FormulaC30H39Cl2N3O
Cas No.1609563-71-4
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8919 mL9.4597 mL18.9193 mL94.5966 mL
5 mM0.3784 mL1.8919 mL3.7839 mL18.9193 mL
10 mM0.1892 mL0.9460 mL1.8919 mL9.4597 mL
20 mM0.0946 mL0.4730 mL0.9460 mL4.7298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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