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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $98 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $289 | In Stock | |
25 mg | $596 | In Stock | |
50 mg | $787 | In Stock | |
100 mg | $1,070 | In Stock | |
1 mL x 10 mM (in DMSO) | $169 | In Stock |
Description | (1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system. |
Targets&IC50 | GPR88-22F cells:603 nM (EC50), GPR88 receptor:56 nM (EC50, HEK293 cell), GPR88 receptor:3 nM (EC50, cell-free assay) |
In vitro | (1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1]. |
Alias | (1R,2R)-2-PCCA(hydrochloride) |
Molecular Weight | 528.56 |
Formula | C30H39Cl2N3O |
Cas No. | 1609563-71-4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (37.84 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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