Shopping Cart

Remove All
Your shopping cart is currently empty

Carabersat

Name: Carabersat
Brand: TargetMol
SKU: T14863
Price: 291 USD
Availability: InStock
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T14863Cas No. 184653-84-7

Alias SB 204269

Carabersat（SB 204269） is a novel and effective anticonvulsant and antiepileptic agent.

Carabersat

😃Good

Purity: 100%

Catalog No. T14863Alias SB 204269Cas No. 184653-84-7

Carabersat（SB 204269） is a novel and effective anticonvulsant and antiepileptic agent.

Pack Size	Price	Availability	Quantity
1 mg	665 €	6-8 weeks
5 mg	1.710 €	6-8 weeks

Bulk & Custom

Add to Cart

Questions

Select Batch

Purity:100%

Resource Download

COA HNMR LCMS FNMR

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Carabersat（SB 204269） is a novel and effective anticonvulsant and antiepileptic agent.
Targets&IC50	Forebrain membranes:7.3 (pKi,rat), Forebrain membranes:40 nM (Kd,rat), Forebrain membranes:53 nM (Kd,mouse)
In vitro	[3H]Carabersat ([3H]SB 204269) binds to rat forebrain membranes with moderate affinity (Kd 40 nM) and pKi values of 7.3[1]. In mouse forebrain membranes, Carabersat is able to bind, and the binding is saturable and stereospecific, with a Kd of 53 nM. The labeled [3H]Carabersat produces a Kd of 32 nM[2]. Carabersat (SB-204269, 1-100 μM) has no effect on Na+ current in cultured hippocampal neurons. It also shows no effect on action potential discharges evoked by elevating external K+[4]. Structurally related to the benzopyran ATP-sensitive potassium channel (KATP) opener cromakalim, Carabersat (SB-204269) has opposite stereochemistry, and its mechanism of action is not thought to involve KATP[3].
In vivo	Significantly elevating anticonvulsant activity in mice, Carabersat (5b) has been observed[1].
Alias	SB 204269

Chemical Properties

Molecular Weight	357.38
Formula	C₂₀H₂₀FNO₄
Cas No.	184653-84-7
Smiles	N(C(=O)C1=CC=C(F)C=C1)[C@H]2C=3C(OC(C)(C)[C@@H]2O)=CC=C(C(C)=O)C3
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Carabersat