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Home > Immunology/Inflammation > HDAC > TMP 195
TMP 195  
Catalog No. T3983    CAS 1314891-22-9
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5mg
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94.00
10mg
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162.00
25mg
In stock
309.00
50mg
In stock
561.00
100mg
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935.00
1g
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0.00
5g
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0.00
10mM * 1mL (in DMSO)
In stock
103.00
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Documents and Quality Management
Purity:98.00% COA Datasheet HNMR HPLC LCMS
Biological Activity:

Product Description:

Selective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 μM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity.

Target:
There are currently no data!
Research Area:
Others
Chemical Information:
Molecular Weight 456.43
Formula C23H19F3N4O3
CAS Number 1314891-22-9
Solubility DMSO: Soluble
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Related Compound Libraries
This product is contained In the following compound libraries:
  • The compound is not included in our libraries at this moment.
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