BFH772
ID:T3599Hot Degree:
Size Price(USD) Stock Qty Select
2mg 72.00 In Stock
5mg 108.00 In Stock
10mg 182.00 In Stock
25mg 368.00 In Stock
50mg 652.00 In Stock
10mM * 1mL (in DMSO) 105.00 In Stock

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

BFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM.

Target

VEGFR2 View more

IC50 Value

3 nM

Diseases and Conditions

Immunology
In vitro
In vivo
Chemical Information:

Molecular Weight

439.39

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C23H16F3N3O3

CAS:

890128-81-1

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

87 mg/mL (198.0 mM)

DMSO

87 mg/mL (198.0 mM)

Water

In vivo

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 2.2759mL 11.3794mL 22.7588mL
5mM 0.4552mL 2.2759mL 11.3794mL
10mM 0.0228mL 1.1379mL 2.2759mL
50mM 0.0046mL 0.2276mL 1.1379mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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