Docetaxel
ID:T1034Hot Degree:
Size Price(USD) Stock Qty Select
2mg 24.00 In Stock
10mg 62.00 In Stock
50mg 154.00 In Stock
10mM * 1mL (in DMSO) 42.00 In Stock

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.

Target

Tubulin chain Microtubule-associated protein Bcl-2 View more

IC50 Value

Diseases and Conditions

Cancer
In vitro
In vivo
Chemical Information:

Molecular Weight

807.88

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C43H53NO14

CAS:

114977-28-5

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

53 mg/mL warmed (65.6 mM)

DMSO

100 mg/mL (123.78 mM)

Water

In vivo

30% PEG400+0.5% Tween80+5% propylene glycol

30 mg/mL

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 1.2378mL 6.189mL 12.3781mL
5mM 0.2476mL 1.2378mL 6.189mL
10mM 0.0124mL 0.6189mL 1.2378mL
50mM 0.0025mL 0.1238mL 0.6189mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

Customers who bought this product also buy
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

If you have additional questions,Please send us a message.

* Required

Products related targets
  • TRx0237 (LMTX) mesylate

    TRx 0237 (LMTX?) mesylate is a second-generation tau protein aggregation inhibitor for the treatment...

  • Ixabepilone (BMS-247550)

    Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubuli...

  • Vinblastine

    Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used t...

  • TAI-1

    TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.

  • Epothilone A

    Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM.

Recently Viewed Products