Lomitapide
ID:T6267Hot Degree:
Size Price(USD) Stock Qty Select
2mg 55.00 9 days
5mg 99.00 9 days
10mg 134.00 9 days
25mg 213.00 9 days
50mg 328.00 9 days
10mM * 1mL (in DMSO) 158.00 9 days

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.

Target

View more

IC50 Value

Diseases and Conditions

Other
In vitro
In vivo
Chemical Information:

Molecular Weight

692.71

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C39H37F6N3O2

CAS:

182431-12-5

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

100 mg/mL warmed (144.36 mM)

DMSO

100 mg/mL (144.36 mM)

Water

<1 mg/mL (<1 mM)

In vivo

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 1.4436mL 7.218mL 14.4361mL
5mM 0.2887mL 1.4436mL 7.218mL
10mM 0.0144mL 0.7218mL 1.4436mL
50mM 0.0029mL 0.1444mL 0.7218mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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