MK571
ID:T3148Hot Degree:
Size Price(USD) Stock Qty Select
5mg 42.00 9 days
10mg 69.00 9 days
25mg 153.00 9 days
50mg 278.00 9 days
100mg 456.00 9 days
10mM * 1mL (in DMSO) 48.00 9 days

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

MK-571 is a selective, orally active?CysLT1 receptor(Cysteinyl leukotriene receptor)?antagonist. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. The estimated Ki for inhibition of the synthesis of K-4′-O-GlcA by MK571 is 19.7 μM. MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol glucuronides and sulphates by Caco-2 cells. MK571 significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. These data show that MK571, in addition to inhibiting MRP2, is a potential inhibitor of enterocyte phase-2 conjugation.

Target

CysLT1 View more

IC50 Value

Diseases and Conditions

Respiratory?system/ Cardiovascular system
In vitro
In vivo
Chemical Information:

Molecular Weight

537.07

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C26H27ClN2O3S2.Na

CAS:

115103-85-0

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

19 mg/mL (35.37 mM)

DMSO

100 mg/mL (186.19 mM)

Water

In vivo

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 1.862mL 9.3098mL 18.6195mL
5mM 0.3724mL 1.862mL 9.3098mL
10mM 0.0186mL 0.931mL 1.862mL
50mM 0.0037mL 0.1862mL 0.931mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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