TBA-354
ID:T3642Hot Degree:
Size Price(USD) Stock Qty Select
2mg 186.00 In Stock
5mg 298.00 In Stock
10mg 429.00 In Stock
10mM * 1mL (in DMSO) 312.00 In Stock

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.

Target

Others View more

IC50 Value

Diseases and Conditions

Respiratory?system/ Immunology
In vitro
In vivo
Chemical Information:

Molecular Weight

436.34

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C19H15F3N4O5

CAS:

1257426-19-9

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

DMSO

≥ 46 mg/mL

Water

In vivo

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 2.2918mL 11.459mL 22.9179mL
5mM 0.4584mL 2.2918mL 11.459mL
10mM 0.0229mL 1.1459mL 2.2918mL
50mM 0.0046mL 0.2292mL 1.1459mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

If you have additional questions,Please send us a message.

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