PF-3274167
ID:T3347Hot Degree:
Size Price(USD) Stock Qty Select
5mg 71.00 9 days
10mg 121.00 9 days
25mg 230.00 9 days
50mg 390.00 9 days
100mg 634.00 9 days
10mM * 1mL (in DMSO) 76.00 9 days

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. Oxytocin receptors are also present in the central nervous system.

Target

OXTR View more

IC50 Value

9.5 nM (Ki)?

Diseases and Conditions

Immunology/ Endocrine system
In vitro
In vivo
Chemical Information:

Molecular Weight

419.11

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C19H19ClFN5O3

CAS:

900510-03-4

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

DMSO

Soluble

Water

In vivo

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 2.386mL 11.93mL 23.8601mL
5mM 0.4772mL 2.386mL 11.93mL
10mM 0.0239mL 1.193mL 2.386mL
50mM 0.0048mL 0.2386mL 1.193mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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