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PI3K-AKT-mTOR Compound Library

Catalog No. L1300

ThePI3K/AKT/mTOR pathwayis an intracellular signaling pathway important in regulating thecell cycle. Therefore, it is directly related to cellularquiescence,proliferation,cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3Kactivationphosphorylatesand activatesAKT, localizing it in theplasma membrane.AKT can have a number of downstream effects such as activatingCREB,inhibitingp27,localizingFOXOin the cytoplasm,activatingPtdIns-3ps,and activatingmTORwhich can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer.

The PI3K/Akt/mTOR Compound Library by TargetMol, containing 190 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

Pack Size Price
100 μL * 10 mM (in DMSO) USD 5438.00
250 μL * 10 mM (in DMSO) USD 8573.00
1 mg USD 8573.00

Product Description

  • A unique collection of 190 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
  • Effective tool for studying cell growth, proliferation, and apoptosis;
  • Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice; Stable for One year as powder, 6 months at - 20 ° C in DMSO or 12months at -80 ° C in DMSO

Library Composition

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