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Compound Libraries JAK STAT Compound Library

JAK STAT Compound Library

Catalog No. L3700
  Library Compound List   Excel SDF

Cell signal transduction is the transmission of molecular signals via various proteins in a signaling cascade, which carries and amplifies the signal. The JAK-STAT signaling pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signaling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2, and there are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.

JAK/STAT Compound Library from TargetMol, a unique collection of 145 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 2320.00
250 μL * 10 mM (in DMSO) 4205.00
1 mg 4205.00
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Product Description

  • A unique collection of 145 JAK/STAT signaling targeted compounds for high throughput and high content screening;
  • Effective tool for studying the JAK/STAT targets;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice.
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Library Composition

EGFR (78)
JAK (42)
STAT (19)
HER (15)
Src (13)
Tyrosine Kinases (13)
FLT (12)
PDGFR (8)
Pim (8)
VEGFR (8)
FGFR (7)
CDK (5)
Bcr-Abl (4)
BTK (4)
c-Kit (4)
IGF-1R (4)
IκB/IKK (2)
PKC (2)
Raf (2)
ROCK (2)
c-RET (2)
ALK (2)
Aurora Kinase (2)
Chk (2)
cholecystokinin (1)
c-Fms (1)
Casein Kinase (1)
DNA/RNA Synthesis (1)
Estrogen/progestogen Receptor (1)
FAAH (1)
HDAC (1)
HIF (1)
ROS (1)
Sodium Channel (1)
PTEN (1)
PKA (1)
MEK (1)
NF-κB (1)
p38 MAPK (1)
PI3K (1)
Syk (1)
Trk receptor (1)
Tyrosinase (1)