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Nsp16-Targeted Compound Library (CADD)

Catalog No. L1715
  Library Compound List   Excel SDF

Most viral mRNAs possess a 5'-terminal cap structure (m7GpppN) which is essential for efficient splicing, nuclear export, translation and stability. This structure undergoes methylation catalyzed by non-structural protein 16 (nsp16), 2'-O-ribose methyltransferase, at the ribose 2'-O position of the first and second nucleotide of the mRNA. Nsp16 provides the viral mRNA with the ability to camouflage and obscure itself from the host cell, thus preventing recognition and activation of the host immune response which is essential for successful viral infection. This protein can, therefore, act as another potential drug target for the SARS-CoV-2.

Based on the protein structure of nsp16 protein, we selected 281 top-ranked docked molecules into Nsp16-Targeted Compound Library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free!

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 281 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting nsp16 protein will improve the hit success rate;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1715)

Library Composition

Adrenergic Receptor (12)
Potassium Channel (7)
Antioxidant (7)
VEGFR (7)
Endogenous Metabolite (7)
Prostaglandin Receptor (6)
Epigenetic Reader Domain (6)
Histone Methyltransferase (5)
FLT (5)
HIV Protease (5)
DNA/RNA Synthesis (5)
PKC (5)
Calcium Channel (4)
Autophagy (4)
RAAS (4)
Antibacterial (4)
Integrin (3)
NF-κB (3)
c-RET (3)
COX (3)
CDK (3)
PPAR (3)
TAM Receptor (3)
Thrombin (3)
TNF (3)
AChR (2)
Histamine Receptor (2)
NADPH (2)
Estrogen/progestogen Receptor (2)
Sirtuin (2)
Sodium Channel (2)
EGFR (2)
Dopamine Receptor (2)
GPR (2)
c-Kit (2)
Gap Junction Protein (2)
PDGFR (2)
ROS (2)
LDL (2)
Transferase (2)
Akt (2)
5-HT Receptor (2)
Aromatase (2)
Antibiotic (2)
P-gp (2)
PKA (2)
PI3K (2)
MT Receptor (1)
mTOR (1)
Lipase (1)
MRP (1)
LHRH (1)
MEK (1)
NADPH-oxidase (1)
lysosomal autophagy (1)
Raf (1)
RAR/RXR (1)
NOD-like Receptor (NLR) (1)
Opioid Receptor (1)
JAK (1)
P2 Receptor (1)
P2X Receptor (1)
p38 MAPK (1)
P450 (1)
p53 (1)
PAI-1 (1)
PD-1/PD-L1 (1)
PDK (1)
Phospholipase (1)
Proteasome (1)
JNK (1)
HDAC (1)
ribosome (1)
TGF-beta/Smad (1)
Acetyl-CoA Carboxylase (1)
Antifolate (1)
Vitamin (1)
Apoptosis (1)
Arginase (1)
Aurora Kinase (1)
Topoisomerase (1)
Cannabinoid Receptor (1)
Carbonic Anhydrase (1)
CaSR (1)
Chk (1)
c-Met/HGFR (1)
TLR (1)
DNA-PK (1)
Influenza Virus (1)
FAAH (1)
Ferroptosis (1)
S6 Kinase (1)
Gamma-secretase (1)
GHSR (1)
Glucokinase (1)
Glutathione reductase (1)
GNRH Receptor (1)
Adenosine Receptor (1)
HER (1)
HIF (1)
S1P Receptor (1)
HSV (1)
Hydroxylase (1)
ERK (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE