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PLpro-Targeted Compound Library (CADD)

Catalog No. L1716
  Library Compound List   Excel SDF

PLpro is responsible for the cleavages of N-terminus of the replicase poly-protein to release Nsp1, Nsp2 and Nsp3, which is essential for correcting virus replication. PLpro was also confirmed to be significant to antagonize the host’s innate immunity. As an indispensable enzyme in the process of coronavirus replication and infection of the host, PLpro has been a popular target for coronavirus inhibitors. It is very valuable for targeting PLpro to treat coronavirus infections, but no inhibitor has been approved by the FDA for marketing.

Based on the protein structure of PLpro, we selected 474 top-ranked docked molecules into PLpro-Targeted Compound Library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free!

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Please contact us for prices and availability for the specification of product you are interested at.
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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 474 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting PLpro will improve the hit success rate;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1716)

Library Composition

VEGFR (7)
Adrenergic Receptor (7)
HDAC (6)
Epigenetic Reader Domain (6)
DNA/RNA Synthesis (6)
Histamine Receptor (5)
Histone Methyltransferase (5)
Potassium Channel (5)
Endogenous Metabolite (4)
COX (4)
Autophagy (4)
Integrin (3)
Dopamine Receptor (3)
MRP (3)
NADPH (3)
5-HT Receptor (3)
P450 (3)
PDGFR (3)
Antioxidant (3)
PPAR (3)
RAAS (3)
Sodium Channel (3)
GPR (2)
PI3K (2)
MMP (2)
JNK (2)
Prostaglandin Receptor (2)
Proteasome (2)
Sirtuin (2)
PDE (2)
LDL (2)
FLT (2)
ERK (2)
Antibiotic (2)
Antiviral (2)
ATM/ATR (2)
BCL (2)
Carbonic Anhydrase (2)
c-Kit (2)
DHFR (2)
Vitamin (2)
HIF (1)
Reverse Transcriptase (1)
Glutaminase (1)
Phosphorylase (1)
Apoptosis (1)
PKA (1)
PKC (1)
PLK (1)
Glucokinase (1)
Antifection (1)
Gap Junction Protein (1)
Antibacterial (1)
Androgen Receptor (1)
RAR/RXR (1)
ROR (1)
PD-1/PD-L1 (1)
S1P Receptor (1)
AMPK (1)
Adenosine Receptor (1)
Src (1)
Stearoyl-CoA Desaturase (SCD) (1)
Survivin (1)
TLR (1)
TNF (1)
Topoisomerase (1)
Trk receptor (1)
Tyrosinase (1)
VDA (1)
AChR (1)
FGFR (1)
PAI-1 (1)
Fatty Acid Synthase (1)
DNA-PK (1)
HER (1)
HIV Protease (1)
HSP (1)
HSV (1)
Hydroxylase (1)
EGFR (1)
E1/E2/E3 Enzyme (1)
Kinesin (1)
ABC (1)
LPA Receptor (1)
lysosomal autophagy (1)
MEK (1)
Microtubule Associated (1)
Ferroptosis (1)
p53 (1)
mTOR (1)
Guanylate cyclase (1)
NADPH-oxidase (1)
NAMPT (1)
Neprilysin (1)
NF-κB (1)
Norepinephrine (1)
CDK (1)
OX Receptor (1)
GABA Receptor (1)
P2X Receptor (1)
p38 MAPK (1)
GTPase (1)
P2 Receptor (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE