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RdRP-Targeted Compound Library (CADD)

Catalog No. L1717
  Library Compound List   Excel SDF

RdRp (Nsp12), a conserved protein in coronavirus, is an RNA-dependent RNA polymerase (RdRp) and the vital enzyme of coronavirus replication/transcription complex. The RdRp domain of polymerase is located at the C-terminus and has a conserved Ser-Asp-Asp motif. Nsp8 can de novo synthesize up to 6 nucleotides in length, which can be used as a primer for Nsp12-RdRp RNA synthesis. Further, the Nsp7_Nsp8 complex increases the binding of Nsp12 to RNA and enhances the RdRps enzyme activity of Nsp12. In the research of SARS-CoV and MERS-CoV inhibitors, Nsp12-RdRp has been used as a very important drug target. In principle, targeted inhibition of Nsp12-RdRp could not cause significant toxicity and side effects on host cells, but no specific inhibitors have been found until now.

Based on the protein structure of RdRP, we selected 464 top-ranked docked molecules into RdRP-Targeted Compound Library (CADD) by molecular docking virtual screening against 15,376 compound structures. To speed up the research and development of anti-SARS-CoV-2 drugs, we provide the virtual screening result for free!

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 464 compounds having the potential of anti-SARS-CoV-2 activity, can be used for high throughput screening and high content screening;
  • Top-ranked docked compounds targeting RdRP will improve the hit success rate;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L1717)

Library Composition

Adrenergic Receptor (11)
Calcium Channel (10)
Antioxidant (8)
HIV Protease (7)
Histone Methyltransferase (6)
DNA/RNA Synthesis (6)
5-HT Receptor (5)
RAAS (5)
Prostaglandin Receptor (5)
Potassium Channel (5)
PI3K (5)
Integrin (5)
Glucokinase (4)
Epigenetic Reader Domain (4)
Dopamine Receptor (4)
Antibiotic (3)
Reverse Transcriptase (3)
NADPH (3)
Antibacterial (3)
Endogenous Metabolite (3)
EGFR (3)
Reductase (3)
PKC (3)
Caspase (3)
VEGFR (3)
ROS (2)
OX Receptor (2)
JAK (2)
Vitamin (2)
LDL (2)
mTOR (2)
Autophagy (2)
Opioid Receptor (2)
Topoisomerase (2)
P450 (2)
Sirtuin (2)
p53 (2)
TLR (2)
Thrombin (2)
STAT (2)
HCV Protease (2)
Akt (2)
AChR (2)
Sodium Channel (2)
Wnt/beta-catenin (2)
NF-κB (2)
c-Met/HGFR (2)
DHFR (2)
Dehydrogenase (2)
CCR (2)
FLT (2)
Ferroptosis (2)
Guanylate cyclase (1)
Proteasome (1)
Raf (1)
RAR/RXR (1)
c-RET (1)
Rho (1)
ribosome (1)
CPT (1)
S1P Receptor (1)
Serine/threonin kinase (1)
Src (1)
COX (1)
ALK (1)
cell cycle arrest (1)
TAM Receptor (1)
TGF-beta/Smad (1)
Aromatase (1)
TNF (1)
BTK (1)
Trk receptor (1)
Tyrosinase (1)
Tyrosine Kinases (1)
Bradykinin Receptor (1)
Bombesin Receptor (1)
Antifolate (1)
Platelet aggregation (1)
PLK (1)
NOD-like Receptor (NLR) (1)
HIF (1)
Histamine Receptor (1)
Antifection (1)
GTPase (1)
HMG-CoA Reductase (1)
Acetyl-CoA Carboxylase (1)
GPR (1)
GHSR (1)
MMP (1)
MRP (1)
Gap Junction Protein (1)
Gamma-secretase (1)
NOS (1)
HDAC (1)
FGFR (1)
Fatty Acid Synthase (1)
P2 Receptor (1)
P2X Receptor (1)
FAK (1)
Estrogen/progestogen Receptor (1)
PAI-1 (1)
PARP (1)
PD-1/PD-L1 (1)
PDE (1)
Phosphatase (1)
Androgen Receptor (1)
DNA-PK (1)
ATPase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE