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(±)-Norcantharidin

Catalog No. T5656 CAS 29745-04-8

Synonyms: Endothall anhydride, Norcantharidin

(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.

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(±)-Norcantharidin, CAS 29745-04-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 71.00
50 mg	In stock	$ 107.00
100 mg	In stock	$ 156.00
500 mg	In stock	$ 383.00
1 g	In stock	$ 568.00

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Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
In vivo	NCTD might be a useful and inexpensive drug candidate to substitute for gefitinib to serve the treatment needs of cancer patients[1].NCTD inhibits the growth of xenografted tumors of human gallbladder carcinoma in nude mice by inducing apoptosis and blocking the cell cycle in vivo[2].
Cell Research	Two human colon cancer cell lines, HCT116 and HT29, were used as model systems to investigate the anti-cancer molecular mechanism of NCTD. Cell cycle arrest and early/late apoptosis were analyzed by flow cytometry. The levels of EGFR, phospho-EGFR, c-Met, phospho-c-Met and other related proteins were quantified by western blot analysis[1]
Animal Research	The tumor xenograft model of human gallbladder carcinoma in nude mice in vivo was established with subcutaneous GBC-SD cells. The experimental mice were randomly divided into control, 5-FU, NCTD, and NCTD+5-FU groups which were given different treatments. Tumor growth in terms of size, growth curve, and inhibitory rate was evaluated. Cell cycle, apoptosis, and morphological changes of the xenografted tumors were assessed by flow cytometry and light/electron microscopy. The expression of the cell cycle-related proteins cyclin-D1 and p27 as well as the apoptosis-related proteins Bcl-2, Bax, and survivin were determined by the streptavidin-biotin complex (SABC) method and RT-PCR[2].

Synonyms	Endothall anhydride, Norcantharidin
Molecular Weight	168.15
Formula	C8H8O4
CAS No.	29745-04-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (196.25 mM)

References and Literature

1. Qiu P , Wang S , Liu M , et al. Norcantharidin Inhibits cell growth by suppressing the expression and phosphorylation of both EGFR and c-Met in human colon cancer cells[J]. BMC Cancer, 2017, 17(1):55. 2. Fan Y Z , Zhao Z M , Fu J Y , et al. Norcantharidin Inhibits Growth of Human Gallbladder Carcinoma Xenografted Tumors in Nude Mice by Inducing Apoptosis and Blocking the Cell Cycle in vivo[J]. Hepatobiliary & Pancreatic Diseases International, 2010, 9(4):414-422.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library

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Keywords

(±)-Norcantharidin 29745-04-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR c-Met/HGFR Endothall anhydride (±) Norcantharidin (±)Norcantharidin Norcantharidin inhibitor inhibit

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