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(±)10(11)-EpDPA

Catalog No. T35493Cas No. 895127-65-8

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.

(±)10(11)-EpDPA
Other Forms of (±)10(11)-EpDPA:
(±)13(14)-EpDPAT35496895127-64-7
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(±)19(20)-EpDPAT37238
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19R(20S)-EpDPAT362182242542-60-3
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(±)7(8)-EpDPAT35497895127-66-9
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(±)16(17)-EpDPAT37235155073-46-4
View details

(±)10(11)-EpDPA

Catalog No. T35493Cas No. 895127-65-8
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.
Pack SizePriceAvailabilityQuantity
25 μg$9835 days
50 μg$19535 days
100 μg$36335 days
500 μg$1,60035 days
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Product Introduction

Bioactivity
Description
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.
Chemical Properties
Molecular Weight344.495
FormulaC22H32O3
Cas No.895127-65-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 50 mg/mL
DMF: 25 mg/mL
DMSO: 20 mg/mL
Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

(±)10(11)EpDPA(±)10(11) EpDPA10(11)-EpDPA
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