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Membrane transporter/Ion channel Chloride channel (+)-Shikonin

(+)-Shikonin

Catalog No. T1125   CAS 517-89-5
Synonyms: Isoarnebin 4, C.I. 75535, Shikonin, Anchusa acid, Alkanna Red, NSC 252844
Purity 99.90% Datasheet

Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TNF-α. Shikonin decreases exosome secretion through the inhibition of glycolysis

(+)-Shikonin, CAS 517-89-5
Pack Size Availability Price/USD Quantity
5 mg In stock 48.00
10 mg In stock 58.00
25 mg In stock 122.00
50 mg In stock 183.00
100 mg In stock 290.00
200 mg In stock 435.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TNF-α. Shikonin decreases exosome secretion through the inhibition of glycolysis
Targets&IC50 TMEM16A chloride channel,   PKM2,   NF-κB,   TNF-α,  
Synonyms Isoarnebin 4 , C.I. 75535 , Shikonin , Anchusa acid , Alkanna Red , NSC 252844
Purity 99.11%
Molecular Weight 288.3
Formula C16H16O5
CAS No. 517-89-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 57 mg/mL

Ethanol: 13 mg/mL(45.1 mM)

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Jiang Y, Yu B, Yang H, et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea[J]. Frontiers in pharmacology, 2016, 7: 270. 2. Li W, Zhang C, Ren A, et al. Shikonin suppresses skin carcinogenesis via inhibiting cell proliferation[J]. PloS one, 2015, 10(5): e20126459. 3. Yan Y, Furumura M, Gouya T, et al. Shikonin promotes skin cell proliferation and inhibits nuclear factor-κB translocation via proteasome inhibition in vitro[J]. Chinese medical journal, 2015, 128(16): 2228. 4. Zhang F Y, Hu Y, Que Z Y, et al. Shikonin inhibits the migration and invasion of human glioblastoma cells by targeting phosphorylated β-catenin and phosphorylated PI3K/Akt: a potential mechanism for the anti-glioma efficacy of a traditional Chinese herbal medicine[J]. International journal of molecular sciences, 2015, 16(10): 23823-23848. 5. Fu D, Shang X, Ni Z, et al. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis[J]. Experimental and therapeutic medicine, 2016, 12(4): 2735-2740. 6. Zhang FY, et al. Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated β-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine. Int J Mol Sci. 2015 Oct 9;16(10):23823-48. 7. Jiang Y et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Natural Compound Library for HTS Selected Plant-sourced Compound Library Phosphatase Inhibitor Library

Related Products

Related compounds with same targets
(+)-Shikonin Strychnine Sulfate Betaine hydrochloride Mitapivat PKM2 inhibitor Anestan Disodium monofluorophosphate ML265

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