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(-)-Curine

Catalog No. TN1156 CAS 436-05-5

(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.

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(-)-Curine, CAS 436-05-5

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Description	(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
In vitro	As in many other cancers, p53 mutations are commonly observed in HCCs (Hussain et al., 2007; Levine et al., 1994) [1,2]. Tumor tissues with mutant p53 seems to be more aggressive and resist to chemotherapy than that harboring wide-type p53 (Harris and Hollstein, 1994; Parrales and Iwakuma, 2015) [3,4]. (-)-Curine, a novel bisbenzylisoquinoline alkaloid, is one of the main components isolated from the roots of Cyclea wattii. Here, it was found to exert cytotoxity on hepatocellular carcinoma (HCC) cells regardless of p53 status. We found that (-)-Curine induced G1 arrest and cell death in HepG2 cells with wild-type p53 as well as Huh-7 cells with mutant p53. In HepG2 cells, knocking down of p53 did not change its cellular responses to (-)-Curine, and same degree of G1 arrest and cell death were occurred after p53 knockdown.
Source	Natural Products > Menispermaceae > Cyclea

Molecular Weight	594.7
Formula	C36H38N2O6
CAS No.	436-05-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. (-)-Curine induces cell cycle arrest and cell death in hepatocellular carcinoma cells in a p53-independent way.Biomed Pharmacother. 2017 May;89:894-901.

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Keywords

(-)-Curine 436-05-5 Apoptosis p53 ( ) Curine Curine ()Curine inhibitor inhibit

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