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(E)-Ferulic acid

Catalog No. T5679 CAS 537-98-4

Synonyms: trans-Ferulic acid, (E)-Coniferic acid

(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.t(E)-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

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(E)-Ferulic acid, CAS 537-98-4

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

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Description	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.t(E)-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
In vitro	trans-Ferulic acid exerted potent antioxidant effects. However, trans-Ferulic acid increased intracellular ROS levels, including hydrogen peroxide and superoxide anion, in H1299 cells. trans-Ferulic acid treatment inhibited cellular proliferation and induced moderate apoptotic cell death at the highest concentration used (0.6 mM). Furthermore, trans-Ferulic acid moderately inhibited the migration of H1299 cells at the concentrations of 0.3 and 0.6 mM and attenuated MMP-2 and MMP-9 activity. trans-Ferulic acid caused the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin. Conversely, trans-Ferulic acid treatment increased the expression of pro-apoptotic factor Bax and decreased the expression of pro-survival factor survivin.
Cell Research	The 2,2-diphenyl-1-picrylhydrazyl assay was used to determine free radical scavenging capability. Assessment of intracellular reactive oxygen species (ROS) was evaluated using oxidized 2',7'-dichlorofluorescin diacetate and dihydroethidium staining. Trypan blue exclusion, colony formation, and anchorage-independent growth assays were used to determine cellular proliferation. Annexin V staining assay was used to assess cellular apoptosis by flow cytometry. Wound healing and Boyden's well assays were used to detect the migration and invasion of cells. Gelatin zymography was used to detect matrix metalloproteinase (MMP-2 and MMP-9) activity. Western blotting was used to detect expression levels of various signaling pathway proteins.
Source	Natural Products > Euphorbiaceae > Euphorbia

Synonyms	trans-Ferulic acid, (E)-Coniferic acid
Molecular Weight	194.18
Formula	C10H10O4
CAS No.	537-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (334.74 mM)

References and Literature

1. Fong Y , Tang C C , Hu H T , et al. Inhibitory effect oftrans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability[J]. Chinese Medicine, 2016, 11(1):45.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tobacco Monomer Library Miao medicine Compound Library Toxic Compound Library Target-Focused Phenotypic Screening Library Mitochondria-Targeted Compound Library Anti-Prostate Cancer Compound Library Natural Product Library for HTS Anti-Ovarian Cancer Compound Library RO5 Drug-like Natural Product Library

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Keywords

(E)-Ferulic acid 537-98-4 Apoptosis Cytoskeletal Signaling Metabolism Stem Cells BCL Ferroptosis Endogenous Metabolite Wnt/beta-catenin Beta catenin trans-Ferulic acid Inhibitor (E) Ferulic acid Bcl-2 Family (E)Ferulic acid Coniferic acid β-catenin Ferulic acid inhibit (E)-Coniferic acid inhibitor

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