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(E/Z)-Polydatin

Catalog No. T2938 CAS 65914-17-2

Synonyms: Polydatin, (E/Z)-Piceid

(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

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(E/Z)-Polydatin, CAS 65914-17-2

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 99.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
In vitro	In a study involving mice with sepsis induced by cecal ligation and puncture, polydatin (15/45/100 mg/kg) was found to inhibit the production of serum TNF-α and IL-6, the protein expression of lung cyclooxygenase-2 and inducible NO synthase isoforms, and the activation of NF-κB, thereby reducing mortality and lung injury in a dose-dependent manner. The LD50 of polydatin in mice was determined to be 1 g/kg (i.p.).
In vivo	Polydatin is a PLA2 inhibitor that reduces the expression of sPLA2-IIA mRNA and the activity of phospholipase A2. It also increases the expression of Clara cell secretory proteins, thereby mitigating lipopolysaccharide-induced lung injury.
Source	Natural Products > Pinaceae > Picea

Synonyms	Polydatin, (E/Z)-Piceid
Molecular Weight	390.38
Formula	C20H22O8
CAS No.	65914-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (184.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Shiyu S, et al. BMC Cell Biol, 2011, 25, 12:31. 2. Li XH, et al. Mediators Inflamm, 2013, 2013, 354087.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Metabolism Disease Compound Library Natural Product Library for HTS Bioactive Lipid Compound Library Anti-Tumor Natural Product Library Apoptosis Compound Library Chinese Pharmacopoeia Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Aging Compound Library Traditional Chinese Medicine Monomer Library

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Keywords

(E/Z)-Polydatin 65914-17-2 Metabolism Phospholipase inhibit cuspidatum Inhibitor Polygonum (E/Z) Polydatin (E/Z)Polydatin Polydatin (E/Z)-Piceid inhibitor

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