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(E/Z)-4-Hydroxytamoxifen

Catalog No. T6743   CAS 68392-35-8
Synonyms: Afimoxifene, 4-Hydroxytamoxifen

(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
(E/Z)-4-Hydroxytamoxifen Chemical Structure
(E/Z)-4-Hydroxytamoxifen, CAS 68392-35-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 72.00
25 mg In stock $ 129.00
50 mg In stock $ 213.00
100 mg In stock $ 328.00
200 mg In stock $ 493.00
500 mg In stock $ 789.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 99.1%
Purity: 99.08%
Purity: 98.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
Targets&IC50 ER:
In vitro 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants
Cell Research Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.
Animal Research Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration
Synonyms Afimoxifene, 4-Hydroxytamoxifen
Molecular Weight 387.51
Formula C26H29NO2
CAS No. 68392-35-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 71 mg/mL (183.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Asp ML, et al. PLoS One. 2013, 8(10):e78768. 2. Beland FA, et al. Carcinogenesis. 1999, 20(3):471-477.

TargetMolCitations

1. Wang D, Yin Z, Wang H, et al.The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma.Science Advances.2023, 9(13): eadf0005.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Endocrinology-Hormone Compound Library Clinical Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Nuclear Receptor Compound Library Human Metabolite Library

Related Products

Related compounds with same targets
ERRγ Inverse Agonist 1 Bazedoxifene acetate Desogestrel DPN 17α-Hydroxyprogesterone Endoxifen E-isomer hydrochloride Drospirenone Promestriene

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Keywords

(E/Z)-4-Hydroxytamoxifen 68392-35-8 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR (E/Z)4Hydroxytamoxifen Inhibitor inhibit (E/Z) 4 Hydroxytamoxifen Endogenous Metabolite Afimoxifene 4-Hydroxytamoxifen inhibitor

 

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