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(R)-3-Hydroxy Midostaurin

Catalog No. T12610   CAS 155848-20-7
Synonyms: (R)-CGP52421

(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).

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(R)-3-Hydroxy Midostaurin Chemical Structure
(R)-3-Hydroxy Midostaurin, CAS 155848-20-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
In vitro (R)-3-Hydroxy Midostaurin against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.
Synonyms (R)-CGP52421
Molecular Weight 586.648
Formula C35H30N4O5
CAS No. 155848-20-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

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Keywords

(R)-3-Hydroxy Midostaurin 155848-20-7 Others CGP-52421 (R)3Hydroxy Midostaurin (R)-CGP52421 CGP 52421 (R) 3 Hydroxy Midostaurin 3-Hydroxy Midostaurin CGP52421 inhibitor inhibit

 

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