Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
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Description | (R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML). |
In vitro | (R)-3-Hydroxy Midostaurin against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive. |
Synonyms | (R)-CGP52421 |
Molecular Weight | 586.648 |
Formula | C35H30N4O5 |
CAS No. | 155848-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(R)-3-Hydroxy Midostaurin 155848-20-7 Others CGP-52421 (R)3Hydroxy Midostaurin (R)-CGP52421 CGP 52421 (R) 3 Hydroxy Midostaurin 3-Hydroxy Midostaurin CGP52421 inhibitor inhibit