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(R)-CR8 trihydrochloride

Catalog No. T12617 CAS 1786438-30-9

Synonyms: CR8, (R)-Isomer trihydrochloride

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.

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(R)-CR8 trihydrochloride Chemical Structure

(R)-CR8 trihydrochloride, CAS 1786438-30-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 100.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 238.00
100 mg	In stock	$ 355.00
1 mL * 10 mM (in DMSO)	In stock	$ 87.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
Targets&IC50	CK1δ/ε:0.4 μM, CDK9-CyclinT1:0.18 μM, CDK2-CyclinE:0.041 μM, CDK1:0.09 μM, CDK5-p25:0.11 μM, CDK7-CyclinH:1.1 μM, CDK2:0.072 μM
In vitro	In the SH-SY5Y cell line, (R)-CR8 trihydrochloride (0.1, 1, 10, 100 μM; 24 hours) reduced cell survival in a dose-dependent manner[1].
In vivo	In 10 to 12-week-old male Sprague-Dawley rats (310 to 330 g), administration of (R)-CR8 trihydrochloride at 5 mg/kg (i.p.) resulted in a significant reduction in lesion size[2].

Synonyms	CR8, (R)-Isomer trihydrochloride
Molecular Weight	540.92
Formula	C24H32Cl3N7O
CAS No.	1786438-30-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (55.46 mM), Sonification is recommended.

References and Literature

1. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. 2. Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(R)-CR8 trihydrochloride 1786438-30-9 Apoptosis Cell Cycle/Checkpoint CDK (R)-CR-8 trihydrochloride (R)CR8 trihydrochloride CR-8 Trihydrochloride CR 8 (R) CR8 trihydrochloride CR8, (R)-Isomer trihydrochloride CR8, Isomer (R)-CR8 trihydrochloride CR 8 Trihydrochloride CR8 CR8 Trihydrochloride CR8, Isomer Trihydrochloride CR-8 inhibitor inhibit

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