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(R)-GNE-140

Catalog No. T4295   CAS 2003234-63-5
Synonyms: GNE-140

(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.

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(R)-GNE-140 Chemical Structure
(R)-GNE-140, CAS 2003234-63-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 67.00
2 mg In stock $ 97.00
5 mg In stock $ 163.00
10 mg In stock $ 279.00
25 mg In stock $ 515.00
50 mg In stock $ 747.00
100 mg In stock $ 1,050.00
500 mg In stock $ 2,080.00
1 mL * 10 mM (in DMSO) In stock $ 178.00
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Purity: 97.32%
Purity: 95.46%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
Targets&IC50 LDHB:5 nM, LDHA:3 nM
In vitro (R)-GNE-140 (5 μM) inhibits proliferation in 37 of 347 cancer cell lines. (R)-GNE-140 has an inhibitory effect on two chondrosarcomas (bone) cancer cell lines that harbor IDH1 mutations (IC50: 0.8 mΜ).
In vivo (R)-GNE-140 (5 mg/kg) has high bioavailability in mice. (R)-GNE-140 (50-200 mg/kg, p.o.) has greater exposure.
Synonyms GNE-140
Molecular Weight 499.04
Formula C25H23ClN2O3S2
CAS No. 2003234-63-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.43 mg/mL (28.92 mM)

H2O: < 0.1 mg/mL (insoluble)

TargetMolReferences and Literature

1. Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901.

TargetMolCitations

1. Zhang Y T, Xing M L, Fang H H, et al.Effects of lactate on metabolism and differentiation of CD4+T cells.Molecular Immunology.2023, 154: 96-107.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Inhibitor Library Target-Focused Phenotypic Screening Library Anti-Cancer Metabolism Compound Library Glutamine Metabolism Compound Library Bioactive Compound Library Anti-Cancer Compound Library Anti-Metabolism Disease Compound Library Glycometabolism Compound Library Bioactive Compounds Library Max

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Keywords

(R)-GNE-140 2003234-63-5 Metabolism Dehydrogenase Inhibitor LDH GNE-140 (R) GNE 140 GNE 140 GNE140 inhibit Lactate Dehydrogenase (R)GNE140 inhibitor

 

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