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(R)-PS210

Catalog No. T12639 CAS 1410101-89-1

(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).

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(R)-PS210, CAS 1410101-89-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 766.00
50 mg	6-8 weeks	$ 995.00
100 mg	6-8 weeks	$ 1,610.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).
Targets&IC50	PDK1:1.8 μM
In vitro	(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay.The maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold.

Molecular Weight	380.31
Formula	C19H15F3O5
CAS No.	1410101-89-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wilhelm A, et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.J Med Chem. 2012 Nov 26;55(22):9817-30.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(R)-PS210 1410101-89-1 Others (R)PS210 PS210 (R)-PS-210 PS-210 (R) PS210 PS 210 inhibitor inhibit

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