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(Rac)-IBT6A

Catalog No. T10626 CAS 1412418-47-3

(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.

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(Rac)-IBT6A, CAS 1412418-47-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 82.00
2 mg	In stock	$ 116.00
5 mg	In stock	$ 179.00
10 mg	In stock	$ 261.00
25 mg	In stock	$ 436.00
50 mg	In stock	$ 643.00
100 mg	In stock	$ 917.00
500 mg	In stock	$ 1,860.00
1 mL * 10 mM (in DMSO)	In stock	$ 193.00

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Purity: 98.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.

Molecular Weight	386.45
Formula	C22H22N6O
CAS No.	1412418-47-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (116.44 mM), Sonification is recommended.

References and Literature

1. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. 2. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. 3. Liu N, et al. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13(18):5147-57.

Related compound libraries

This product is contained In the following compound libraries：

Covalent Inhibitor Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

zanubrutinib Avitinib JAK3/BTK-IN-1 JDB175 Orelabrutinib RSH-7 BMS-986142 BTK inhibitor 1

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(Rac)-IBT6A 1412418-47-3 Angiogenesis Others Tyrosine Kinase/Adaptors BTK Bruton tyrosine kinase Inhibitor inhibit (Rac)IBT6A IBT6A Btk (Rac) IBT6A (Rac)-IBT-6A inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.