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(Rac)-Rotigotine hydrochloride

Catalog No. T12676 CAS 102120-99-0

(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.

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(Rac)-Rotigotine hydrochloride Chemical Structure

(Rac)-Rotigotine hydrochloride, CAS 102120-99-0

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1 mL * 10 mM (in DMSO)	5 days	$ 52.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
Targets&IC50	D1 receptor:83 nM (Ki), D4 receptor:3.9-15 nM (Ki), D3 receptor:0.71 nM (Ki), 5-HT2B receptor:27 nM (Ki), 5-HT1A receptor:30 nM (Ki), D5 receptor:5.4 nM (Ki), D2 receptor:13.5 nM (Ki)
In vitro	In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. .

Molecular Weight	351.93
Formula	C19H26ClNOS
CAS No.	102120-99-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (142.07 mM)

References and Literature

1. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. 2. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. 3. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91. 4. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

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Keywords

(Rac)-Rotigotine hydrochloride 102120-99-0 GPCR/G Protein Neuroscience Dopamine Receptor Rotigotine Hydrochloride (Rac) Rotigotine hydrochloride (Rac)Rotigotine hydrochloride inhibitor inhibit

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