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(S)-Sunvozertinib

Catalog No. T9304 CAS 2370013-49-1

Synonyms: HER1, Her2, (S)Sunvozertinib, mutant forms of ErbB, Epidermal growth factor receptor, (S)-Sunvozertinib, lung, DZD9008, ErbB-1, inhibit, Btk, breast cancer, N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide, (S)-DZD9008, Inhibitor, EGFR, Bruton tyrosine kinase, (S) Sunvozertinib

DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(S)-Sunvozertinib, CAS 2370013-49-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
Targets&IC50	EGFR exon 20 ASV insertion:51.9 nM (IC50), Her2 exon 20 YVMA insertion:21.2 nM (IC50), EGFR L858R/T790M:1 nM (IC50), EGFR exon 20 NPH:51.2 nM (IC50)

Synonyms	HER1, Her2, (S)Sunvozertinib, mutant forms of ErbB, Epidermal growth factor receptor, (S)-Sunvozertinib, lung, DZD9008, ErbB-1, inhibit, Btk, breast cancer, N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide, (S)-DZD9008, Inhibitor, EGFR, Bruton tyrosine kinase, (S) Sunvozertinib
Molecular Weight	584.09
Formula	C29H35ClFN7O3
CAS No.	2370013-49-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (94.16 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Zhou Q , Gan B , Hong Q , et al. JCES01.17 A Phase I Dose Expansion Study of Epitinib to Evaluate Efficacy and Safety in EGFR Mutation Positive (EGFRm+) NSCLC Patients with Brain Metastasis[J]. Journal of Thoracic Oncology, 2017, 12(1):S236-S237.

Related Products

Related compounds with same targets

AV-412 free base Corylifol C 4-Hydroxycinnamamide Nimotuzumab CP-724714 Chamigrenal BMS-599626 O-Desmethyl gefitinib D8

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.