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(S,R,S)-AHPC-C4-NH2 dihydrochloride

Catalog No. T18665 CAS 2341796-78-7

Synonyms: VH032-C4-NH2 dihydrochloride

(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1].

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(S,R,S)-AHPC-C4-NH2 dihydrochloride Chemical Structure

(S,R,S)-AHPC-C4-NH2 dihydrochloride, CAS 2341796-78-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Synonyms	VH032-C4-NH2 dihydrochloride
Molecular Weight	602.6
Formula	C27H41Cl2N5O4S
CAS No.	2341796-78-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

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Keywords

(S,R,S)-AHPC-C4-NH2 dihydrochloride 2341796-78-7 Others (S,R,S)-AHPC-C-4-NH2 dihydrochloride (S,R,S) AHPC C4 NH2 dihydrochloride AHPC-C4-NH2 Dihydrochloride AHPC-C4-NH2 VH032-C4-NH2 VH032-C4-NH2 Dihydrochloride (S,R,S)AHPCC4NH2 dihydrochloride VH032-C4-NH2 dihydrochloride inhibitor inhibit

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