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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

Catalog No. T18675 CAS 2341796-76-5

Synonyms: VH032 amide-PEG2-amine, VH032-PEG2-NH2 dihydrochloride, VH032-linker 12

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker[1].

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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride Chemical Structure

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride, CAS 2341796-76-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 255.00

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Biological Description

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Description	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker[1].
In vitro	PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Synonyms	VH032 amide-PEG2-amine, VH032-PEG2-NH2 dihydrochloride, VH032-linker 12
Molecular Weight	648.64
Formula	C28H43Cl2N5O6S
CAS No.	2341796-76-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

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(S,S,S)-AHPC hydrochloride Lenalidomide-Br Thalidomide-O-amido-C6-NH2 TFA CC-885 TL12-186 Thalidomide-propargyl E3 ligase Ligand 8 Thalidomide-O-amido-C4-N3

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride 2341796-76-5 Others PROTAC Ligand for E3 Ligase VH032 amide-PEG2-amine (S,R,S) AHPC PEG2 NH2 dihydrochloride VH032-PEG2-NH2 Dihydrochloride VH032-PEG2-NH2 dihydrochloride (S,R,S)-AHPC-PEG-2-NH2 dihydrochloride Inhibitor AHPC-PEG2-NH2 Dihydrochloride VH032-PEG2-NH2 inhibit E3 Ligase Ligand-Linker Conjugates VH032-linker 12 AHPC-PEG2-NH2 (S,R,S)AHPCPEG2NH2 dihydrochloride inhibitor

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