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α-Lipoic Acid

Catalog No. T2930   CAS 62-46-4
Synonyms: Lipoic acid, Alphalipoic acid

α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.

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α-Lipoic Acid Chemical Structure
α-Lipoic Acid, CAS 62-46-4
Pack Size Availability Price/USD Quantity
500 mg In stock $ 47.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 99.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.
In vitro α-Lipoic Acid (Alpha-Lipoic acid, ALA) is a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics.?It reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway.?Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01).?Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells.?α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion
In vivo Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice.?In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1]
Animal Research C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid.?Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed[1].
Synonyms Lipoic acid, Alphalipoic acid
Molecular Weight 206.32
Formula C8H14O2S2
CAS No. 62-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (242.34 mM)

TargetMolReferences and Literature

1. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. 2. Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139. 3. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Natural Product Library Anti-Pancreatic Cancer Compound Library Mitochondria-Targeted Compound Library Endoplasmic Reticulum Stress Compound Library Anti-Tumor Natural Product Library RO5 Drug-like Natural Product Library

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Keywords

α-Lipoic Acid 62-46-4 Metabolism Microbiology/Virology NF-Κb Proteases/Proteasome NF-κB HIV Protease Mitochondrial Metabolism Endogenous Metabolite α Lipoic Acid Lipoic acid alpha-Lipoic Acid Alphalipoic acid a-Lipoic Acid αLipoic Acid inhibitor inhibit

 

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