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α-Spinasterol

Catalog No. TN1377 CAS 481-18-5

Synonyms: alpha-Spinasterol

α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.

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α-Spinasterol, CAS 481-18-5

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1 mg	In stock	$ 67.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 278.00
25 mg	In stock	$ 475.00
50 mg	In stock	$ 682.00

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Purity: 99.58%

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Description	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.
Targets&IC50	COX-2:7.76 μM (IC50), COX-1:16.17 μM (IC50)
In vivo	Oral administration of α-spinasterol reduced postoperative pain, when given as a pre- (0.5 h before incision) or post-treatment (0.5 h after incision), and reduced cell infiltration in the injured tissue.?α-Spinasterol also reduced the mechanical allodynia induced by partial sciatic nerve ligation and the mechanical and cold allodynia induced by paclitaxel.?Moreover, α-spinasterol inhibited COX-1 and COX-2 enzyme activities without altering the body temperature of animals.?Importantly, α-spinasterol did not alter spontaneous or forced locomotor activity.?Furthermore, it did not cause gastric damage or liver and kidney changes, nor did it alter cell viability in the cerebral cortex and spinal cord slices of mice.
Source	Natural Products > Apiaceae > Bupleurum

Synonyms	alpha-Spinasterol
Molecular Weight	412.69
Formula	C29H48O
CAS No.	481-18-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: insoluble

DMSO: insoluble

References and Literature

1. Indiara, Brusco, Camila, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice.[J]. British Journal of Pharmacology, 2017.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library Bioactive Lipid Compound Library Anti-Infection Compound Library Natural Product Library for HTS Anti-infective Natural Product Library Anti-Cardiovascular Disease Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Human Endogenous Metabolite Compound Library Plus NO PAINS Compound Library

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Keywords

α-Spinasterol 481-18-5 Immunology/Inflammation Membrane transporter/Ion channel Microbiology/Virology Neuroscience COX Antibacterial TRP/TRPV Channel inhibit Bacterial TRP Channel α Spinasterol alpha-Spinasterol αSpinasterol Inhibitor Transient receptor potential channels Cyclooxygenase a-Spinasterol inhibitor

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