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β-Aminopropionitrile

Catalog No. T13475 CAS 151-18-8

Synonyms: 3-Aminopropionitrile, BAPN

β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.

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β-Aminopropionitrile, CAS 151-18-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.
In vitro	β-Aminopropionitrile inhibited the invasion and migration capacities of cervical carcinoma cells and blocked the hypoxia-induced EMT morphological and marker protein changes[1].

Synonyms	3-Aminopropionitrile, BAPN
Molecular Weight	70.09
Formula	C3H6N2
CAS No.	151-18-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51. 2. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8. 3. Deng Y, Luo H, Deng Y, et al. Lysyl Oxidase Down-Regulates The Osteoblastic Potential of BMP9 Through Inhibiting HIF-1α/Wnt/β-Catenin Axis in Mesenchymal Stem Cells[J]. 2021

Citations

1. Zhang J, Ye F L, Ye A H, et al.Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells.Journal of Orthopaedic Surgery and Research.2023, 18(1): 911. 2. Peng X, Yuan H, Chen G, et al.Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway.Cellular and Molecular Biology.2023, 69(13): 96-101.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Human Metabolite Library Bioactive Compounds Library Max Antidepressant Compound Library ReFRAME Related Library Bioactive Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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