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1-Aminocyclopropane-1-carboxylic acid

Catalog No. T4752 CAS 22059-21-8

Synonyms: 1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropane, ACC

1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.

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1-Aminocyclopropane-1-carboxylic acid Chemical Structure

1-Aminocyclopropane-1-carboxylic acid, CAS 22059-21-8

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 46.00
1 mL * 10 mM (in H2O)	In stock	$ 48.00

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Purity: 97.91%

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Description	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
Targets&IC50	NMDAR:0.7-0.9 µM (EC50)
In vivo	The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity, however, is mostly presented as a set of disorganized abnormal movements that include tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 μg, at 9 μg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 μg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 μg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs[1].

Synonyms	1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropane, ACC
Molecular Weight	101.1
Formula	C4H7NO2
CAS No.	22059-21-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Bleecker, A.B., et al. A gaseous signal molecule in plants Annual Reviews of Cell Development and Biology 16, 1-18 (2000). 2. Nahum-Levy R., et al. Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors. Molecular Pharmacology 56(6), 1207-1218 (1999).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Human Endogenous Metabolite Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Parkinson's Disease Compound Library Neurotransmitter Receptor Compound Library Human Metabolite Library

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Keywords

1-Aminocyclopropane-1-carboxylic acid 22059-21-8 Metabolism Neuroscience Endogenous Metabolite NMDAR 1-Aminocyclopropanecarboxylic acid 1 Aminocyclopropane 1 carboxylic acid 1Aminocyclopropane1carboxylic acid inhibit 1-Amino-1-carboxycyclopropane ACC Inhibitor inhibitor

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