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18β-Glycyrrhetinic acid

Catalog No. T0036 CAS 471-53-4

Synonyms: Enoxolone, Glycyrrhetin

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

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18β-Glycyrrhetinic acid Chemical Structure

18β-Glycyrrhetinic acid, CAS 471-53-4

Pack Size	Availability	Price/USD
500 mg	In stock	$ 43.00
5 g	In stock	$ 61.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.64%

Purity: 99.55%

Purity: 99.04%

Purity: 99.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
In vitro	MTS assay demonstrates that 24 h treatment of Enoxolone suppresses cell proliferation in both cell lines in a dose-dependent manner. Enoxolone at 160 μM significantly decreases the percentage of viable cells to around 40.5±10.5% in A549 and 38.3±4.6% in NCI-H460 (p<0.01 respectively). When the cells are treated with 320 μM Enoxolone, a greater inhibitory effects on cell proliferation is shown, as the percentage of viable cells is below 30% compare with untreated controls (p<0.001). Treatment with Enoxolone at 160 μM and 320 μM decreases the levels of full-length PARP and increases the levels of cleaved-PARP.
In vivo	Rats in Enoxolone+Triptolide (TP) group which receive low-dose Enoxolone (50?mg/kg) have significant reductions in the three serum parameters when compare with TP rats. Rats in Enoxolone+TP group which receive the high-dose Enoxolone (100?mg/kg) have slightly lowered the levels of three liver enzymes, the reductions do not reach statistical significance compare with TP group. Contrastingly, preadministration of low-dose Enoxolone protects animals from TP-induced hepatic lesions. On the contrary, low-dose Enoxolone (50?mg/kg) markedly suppresses the release of the four cytokines above.
Source	Natural Products > Fabaceae > Glycyrrhiza

Synonyms	Enoxolone, Glycyrrhetin
Molecular Weight	470.68
Formula	C30H46O4
CAS No.	471-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 87 mg/mL (184.8 mM)

References and Literature

1. Boldt J, et al. Expert Opin PharmacOthers. 2007, 8(13):2135-47.

Citations

1. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Tobacco Monomer Library Anti-Metabolism Disease Compound Library Anti-Fibrosis Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Food as Medicine Compound Library NO PAINS Compound Library Anti-Cancer Metabolism Compound Library Covalent Inhibitor Library

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Keywords

18β-Glycyrrhetinic acid 471-53-4 Metabolism Dehydrogenase Endogenous Metabolite Enoxolone Inhibitor 18b-Glycyrrhetinic acid 18β Glycyrrhetinic acid 18βGlycyrrhetinic acid inhibit Glycyrrhetin 18beta-Glycyrrhetinic acid inhibitor

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