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2,2,2-Trichloroethanol

Catalog No. T37709 CAS 115-20-8

2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.

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2,2,2-Trichloroethanol Chemical Structure

2,2,2-Trichloroethanol, CAS 115-20-8

Pack Size	Availability	Price/USD
500 mg	In stock	$ 39.00
5 g	In stock	$ 129.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.
In vitro	2,2,2-trichloroethanol dilated the middle cerebral artery and activated the potassium channel in cerebrovascular smooth muscle[1].

Molecular Weight	149.4
Formula	C2H3Cl3O
CAS No.	115-20-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (669.34 mM)

References and Literature

1. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

Related compound libraries

This product is contained In the following compound libraries：

Ion Channel Inhibitor Library Natural Product Library Human Endogenous Metabolite Compound Library Plus RO5 Drug-like Natural Product Library Anti-Cancer Compound Library Bioactive Compound Library Human Metabolite Library Bioactive Compounds Library Max Natural Product Library for HTS Mouse Metabolite Compound Library

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Keywords

2,2,2-Trichloroethanol 115-20-8 Membrane transporter/Ion channel Metabolism Potassium Channel Endogenous Metabolite nonclassical KcsA non-classical 2,2,2 Trichloroethanol Inhibitor channel hypnotic inhibit chloral 2,2,2Trichloroethanol KCNK4 KCNK2 potassium TRAAK TREK-1 K(+) hydrate channels inhibitor

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