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2,3-Dihydroxy-4-methoxyacetophenone

Catalog No. TN2703 CAS 708-53-2

Synonyms: 2',3'-Dihydroxy-4'-methoxyacetophenone, 2,3-二羟基-4-甲氧基苯乙酮水合物

2,3-Dihydroxy-4-methoxyacetophenone is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

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2,3-Dihydroxy-4-methoxyacetophenone, CAS 708-53-2

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Purity: 98%

Biological Description

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Description

2,3-Dihydroxy-4-methoxyacetophenone is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

In vivo

Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine.?In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine.?2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM).?Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity.?2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.?2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

Synonyms	2',3'-Dihydroxy-4'-methoxyacetophenone, 2,3-二羟基-4-甲氧基苯乙酮水合物
Molecular Weight	182.17
Formula	C9H10O4
CAS No.	708-53-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

2. Weon J B , Ko H J , Ma C J . The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(24):6732-6736.

Related compound libraries

This product is contained In the following compound libraries：

Calcium Antagonist Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Polyphenolic Natural Product Library Natural Product Library for HTS Ion Channel Inhibitor Library Covalent Inhibitor Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library Selected Plant-Sourced Compound Library

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Keywords

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