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2,3-Dihydroxy-4-methoxyacetophenone

Catalog No. TN2703 CAS 708-53-2

Synonyms: 2',3'-Dihydroxy-4'-methoxyacetophenone

2,3-Dihydroxy-4-methoxyacetophenone (2',3'-Dihydroxy-4'-methoxyacetophenone) is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

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2,3-Dihydroxy-4-methoxyacetophenone Chemical Structure

2,3-Dihydroxy-4-methoxyacetophenone, CAS 708-53-2

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50 mg	In stock	$ 42.00
100 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Description	2,3-Dihydroxy-4-methoxyacetophenone (2',3'-Dihydroxy-4'-methoxyacetophenone) is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
In vivo	Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine.?In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine.?2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM).?Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity.?2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.?2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
Source	Natural Products > Asclepiadaceae > Cynanchum

Synonyms	2',3'-Dihydroxy-4'-methoxyacetophenone
Molecular Weight	182.17
Formula	C9H10O4
CAS No.	708-53-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (123.51 mM)

References and Literature

2. Weon J B , Ko H J , Ma C J . The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(24):6732-6736.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Polyphenolic Natural Product Library Tibetan medicine Compound Library Metabolism Compound Library Bioactive Compound Library Natural Product Library for HTS Ion Channel Inhibitor Library Natural Product Library Neuronal Signaling Compound Library RO5 Drug-like Natural Product Library

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Keywords

2,3-Dihydroxy-4-methoxyacetophenone 708-53-2 Membrane transporter/Ion channel Metabolism Calcium Channel inhibit 2,3Dihydroxy4methoxyacetophenone Inhibitor 2,3 Dihydroxy 4 methoxyacetophenone 2',3'-Dihydroxy-4'-methoxyacetophenone inhibitor

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