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2,5-Dihydroxyacetophenone

Catalog No. TCS2170 CAS 490-78-8

Synonyms: Quinacetophenone, 2-Acetylhydroquinone, 2-5-dihydroxyacetophenone, Acetylhydroquinone, DHAP

1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2,5-Dihydroxyacetophenone (Quinacetophenone) has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2,5-Dihydroxyacetophenone (Quinacetophenone) is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.

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2,5-Dihydroxyacetophenone Chemical Structure

2,5-Dihydroxyacetophenone, CAS 490-78-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 45.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.91%

Biological Description

Chemical Properties

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Description

Source

Natural Products > Rutaceae > Citrus

Synonyms	Quinacetophenone, 2-Acetylhydroquinone, 2-5-dihydroxyacetophenone, Acetylhydroquinone, DHAP
Molecular Weight	152.15
Formula	C8H8O3
CAS No.	490-78-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL(184 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Han Y , Jung H W , Lee J Y , et al. 2,5-Dihydroxyacetophenone Isolated from Rehmanniae Radix Preparata Inhibits Inflammatory Responses in Lipopolysaccharide-Stimulated RAW264.7 Macrophages[J]. Journal of Medicinal Food, 2012, 15(6):505-510.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tobacco Monomer Library Kinase Inhibitor Library Natural Product Library for HTS Tibetan medicine Compound Library Bioactive Compounds Library Max Food as Medicine Compound Library Pyroptosis Compound Library Antioxidant Compound Library Anti-Aging Compound Library

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Keywords

2,5-Dihydroxyacetophenone 490-78-8 MAPK NF-Κb Proteases/Proteasome ERK NF-κB Tyrosinase p65 Rehmanniae Preparata Quinacetophenone mediators mRNA iNOS 2-Acetylhydroquinone 2-5-dihydroxyacetophenone 2,5 Dihydroxyacetophenone Inhibitor Nuclear factor-kappaB Nuclear factor-κB Extracellular signal regulated kinases inflammatory 2,5Dihydroxyacetophenone Radix TNF-α IL-6 Acetylhydroquinone DHAP RAW264.7 LPS-stimulated inhibit macrophages inhibitor

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