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2-Acetylbenzoic acid

Catalog No. TMA0536 CAS 577-56-0

2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis.

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2-Acetylbenzoic acid, CAS 577-56-0

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20 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.57%

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Description	2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis.
In vitro	A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-Acetylbenzoic acid had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action[1].
Source	Natural Products > Balsaminaceae > Impatiens

Molecular Weight	164.16
Formula	C9H8O3
CAS No.	577-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (335.04 mM)

References and Literature

1. Killackey JJ, Killackey BA, Philp RB. Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity. Prostaglandins Leukot Med. 1982 Jul;9(1):9-

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compounds Library Max Natural Product Library for HTS Natural Product Library Bioactive Compound Library Selected Plant-Sourced Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Traditional Chinese Medicine Monomer Library RO5 Drug-like Natural Product Library

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Keywords

2-Acetylbenzoic acid 577-56-0 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor 2 Acetylbenzoic acid 2Acetylbenzoic acid inhibitor inhibit

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