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CCPA

Catalog No. T21519 CAS 37739-05-2

Synonyms: 2-chloro-N(6)cyclopentyladenosine, 2-CHLORO-N-CYCLOPENTYLADENOSINE

CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor

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CCPA, CAS 37739-05-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 628.00
100 mg	In stock	$ 888.00
500 mg	In stock	$ 1,770.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 99.91%

Biological Description

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Description	CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor
Targets&IC50	A1 receptor:40 nM
In vitro	CCPA suppressed the mRNA and protein expressions of CnAβ and exerted antihypertrophic effects to a greater degree than CsA. The inhibition of CCPA on cardiomyocyte hypertrophy was counteracted by the A1 receptor antagonist DPCPX[1].
In vivo	CCPA (CCPA) was synthesized as a potential high affinity ligand for A1 adenosine receptors. Binding of [3H]PIA to A1 receptors of rat brain membranes was inhibited by CCPA with a Ki-value of 0.4 nM, compared to a Ki-value of 0.8 nM for the parent compound N6-cyclopentyladenosine (CPA)[2].

Synonyms	2-chloro-N(6)cyclopentyladenosine, 2-CHLORO-N-CYCLOPENTYLADENOSINE
Molecular Weight	369.8
Formula	C15H20ClN5O4
CAS No.	37739-05-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (148.73 mM)

References and Literature

1. Zhang X , Xia J , Qian D , et al. An adenosine A1 agonist 2-chloro-N6 cyclopentyladenosine inhibits the angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin pathway.[J]. Cardiology, 2014, 129(3):153-62. 2. Lohse M J , Klotz K N , Schwabe U , et al. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 1988, 337(6):687-689.

Citations

1. Zhang L, Chen X, Li M, et al.Activation of the adenosine A1 receptor in the lumbosacral spinal cord improves bladder overactivity in rats with cystitis induced by cyclophosphamide.International Urology and Nephrology.2023: 1-9.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Human Metabolite Library Bioactive Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library NO PAINS Compound Library Nucleotide Compound Library Neurotransmitter Receptor Compound Library

Related Products

Related compounds with same targets

Selodenoson N6-(2-Phenylethyl)adenosine 2-Chloroadenosine PSB-603 CGS 21680 Hydrochloride DPCPX PSB 0777 ammonium hydrate Pentostatin

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Keywords

CCPA 37739-05-2 GPCR/G Protein Neuroscience Adenosine Receptor 2-chloro-N(6)cyclopentyladenosine 2 Chloro N6 cyclopentyladenosine 2-Chloro-N-6-cyclopentyladenosine 2-CHLORO-N-CYCLOPENTYLADENOSINE 2ChloroN6cyclopentyladenosine inhibitor inhibit

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