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2-Furoic acid

Catalog No. T5544   CAS 88-14-2
Synonyms: Furan-2-carboxylic acid

2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect.

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2-Furoic acid Chemical Structure
2-Furoic acid, CAS 88-14-2
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100 mg In stock $ 41.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Biological Description
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Description 2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect.
In vitro Agar that contains trace amounts of 5-HMFA and Furan-2-carboxylic acid inhibits the proliferation of some slow-growing or difficult-to-culture bacteria on the plates[1].
In vivo Furan-2-carboxylic acid selectively inhibited bone resorbing activities of osteoclasts and prevented bone loss induced by estrogen deficiency but did not affect bone formation. Furan-2-carboxylic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis[2].
Cell Research The inhibitory effects of 5-HMFA, FA, and a mixture of the furan-2-carboxylic acids on the swarming and swimming of P. collierea V5-G'5 were assayed on MW solid medium (pH 6.0) containing 0.3% washed agar. The concentrations of these compounds were determined by the concentrations found in 0.3% agar plates (1×), and a series of two fold dilutions ranging from 0.125× to 8× was tested. As 5-HMFA and FA remained in the washed agar at concentrations of 0.07 and 0.12 μg g?1 agar, respectively, the 0.3% agar medium supplemented with 0.125× furan-2-carboxylic acids, contained 0.32 ng mL?1 and 0.51 ng mL?1 FA, respectively[1].
Animal Research When given orally twice daily for 4 weeks to 3-month-old ovariectomized (OVX) rats, Furan-2-carboxylic acid dose-dependently prevented bone loss, as monitored by bone densitometry, ash content, and urinary excretion of deoxypyridinoline.?No change in serum osteocalcin in the OVX rats by Furan-2-carboxylic acid suggested that bone formation might not be affected by the agent[2].
Synonyms Furan-2-carboxylic acid
Molecular Weight 112.08
Formula C5H4O3
CAS No. 88-14-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (892.22 mM)

TargetMolReferences and Literature

1. Hara S, Isoda R, Tahvanainen T, et al. Trace Amounts of Furan-2-Carboxylic Acids Determine the Quality of Solid Agar Plates for Bacterial Culture[J]. Plos One, 2012, 7(7):e41142. 2. Kim, M. K . An Orally Active Cathepsin K Inhibitor, Furan-2-Carboxylic Acid, 1-?-cyclohexyl)-amide (OST-4077), Inhibits Osteoclast Activity in Vitro and Bone Loss in Ovariectomized Rats[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 318(2):555-562.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Microbial Natural Product Library Lipid Metabolism Compound Library Metabolism Compound Library High Solubility Fragment Library Food as Medicine Compound Library Anti-Infection Compound Library High Solubility 3D Diversity Fragment Library Natural Product Library Human Metabolite Library

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Keywords

2-Furoic acid 88-14-2 Metabolism Microbiology/Virology Endogenous Metabolite ATP Citrate Lyase Anti-infection Acyltransferase Diglyceride acyltransferase inhibit Diacylglycerol acyltransferase Furan-2-carboxylic acid ACLY mono- acylglycerol acyltransferase Inhibitor 2Furoic acid acyl-CoA:cholesterol acyltransferase 2 Furoic acid inhibitor

 

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