Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 41.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | 2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect. |
In vitro | Agar that contains trace amounts of 5-HMFA and Furan-2-carboxylic acid inhibits the proliferation of some slow-growing or difficult-to-culture bacteria on the plates[1]. |
In vivo | Furan-2-carboxylic acid selectively inhibited bone resorbing activities of osteoclasts and prevented bone loss induced by estrogen deficiency but did not affect bone formation. Furan-2-carboxylic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis[2]. |
Cell Research | The inhibitory effects of 5-HMFA, FA, and a mixture of the furan-2-carboxylic acids on the swarming and swimming of P. collierea V5-G'5 were assayed on MW solid medium (pH 6.0) containing 0.3% washed agar. The concentrations of these compounds were determined by the concentrations found in 0.3% agar plates (1×), and a series of two fold dilutions ranging from 0.125× to 8× was tested. As 5-HMFA and FA remained in the washed agar at concentrations of 0.07 and 0.12 μg g?1 agar, respectively, the 0.3% agar medium supplemented with 0.125× furan-2-carboxylic acids, contained 0.32 ng mL?1 and 0.51 ng mL?1 FA, respectively[1]. |
Animal Research | When given orally twice daily for 4 weeks to 3-month-old ovariectomized (OVX) rats, Furan-2-carboxylic acid dose-dependently prevented bone loss, as monitored by bone densitometry, ash content, and urinary excretion of deoxypyridinoline.?No change in serum osteocalcin in the OVX rats by Furan-2-carboxylic acid suggested that bone formation might not be affected by the agent[2]. |
Synonyms | Furan-2-carboxylic acid |
Molecular Weight | 112.08 |
Formula | C5H4O3 |
CAS No. | 88-14-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (892.22 mM)
You can also refer to dose conversion for different animals. More
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2-Furoic acid 88-14-2 Metabolism Microbiology/Virology Endogenous Metabolite ATP Citrate Lyase Anti-infection Acyltransferase Diglyceride acyltransferase inhibit Diacylglycerol acyltransferase Furan-2-carboxylic acid ACLY mono- acylglycerol acyltransferase Inhibitor 2Furoic acid acyl-CoA:cholesterol acyltransferase 2 Furoic acid inhibitor