Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias.
Description | 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias. |
In vitro | 2-Methylcitric acid compromises glutamate metabolism and triggers permeability transition in brain mitochondria by inhibiting glutamate dehydrogenase (GDH) at concentrations as low as 0.5 mM. At levels between 1-3 mM over 150 seconds, it significantly reduces mitochondrial membrane potential and causes swelling in Ca2+-laden mitochondria with various substrates. It acts as a potent block to glutamate oxidation through GDH activity inhibition and induces permeability transition, thus disrupting mitochondrial energy balance. However, 2-Methylcitric acid does not markedly affect mitochondrial glutamate transport, including in liver mitochondria. |
Synonyms | Methylcitric acid |
Molecular Weight | 206.15 |
Formula | C7H10O7 |
CAS No. | 6061-96-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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2-Methylcitric acid 6061-96-7 Others 2Methylcitric acid Methylcitric acid 2 Methylcitric acid inhibitor inhibit