Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM, and it has anti-inflammatory, anti-proliferative and anti-HIV activity.
Description | 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM, and it has anti-inflammatory, anti-proliferative and anti-HIV activity. |
Targets&IC50 | HIV-1, A018 isolate:0.20 μM, HIV-1, A012 isolate:0.15, S-adenosylhomocysteine hydrolase:(ki)3.9 μM |
In vitro | 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC50s of 0.15 and 0.20 μM, respectively[1]. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine[2]. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling[3]. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. |
Molecular Weight | 266.25 |
Formula | C11H14N4O4 |
CAS No. | 6736-58-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL (488.26 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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3-Deazaadenosine 6736-58-9 Microbiology/Virology Proteases/Proteasome HIV Protease 3 Deazaadenosine 3Deazaadenosine inhibitor inhibit