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3-Epioleanolic acid

Catalog No. TN1248   CAS 25499-90-5

3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.

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3-Epioleanolic acid Chemical Structure
3-Epioleanolic acid, CAS 25499-90-5
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1 mg In stock $ 156.00
5 mg In stock $ 333.00
10 mg In stock $ 568.00
25 mg In stock $ 897.00
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1 mL * 10 mM (in DMSO) In stock $ 388.00
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Purity: 98.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.
In vitro In this investigation, the uterotonic properties of extracts from this tree were evaluated using both pregnant and non-pregnant guinea pig uterine smooth muscle in vitro. The extracts were prepared using water modified supercritical carbon dioxide at 400 atm and 80 degrees C. As samples of these extracts displayed positive results when screened for uterotonic activity, gravity column chromatography followed by NMR spectroscopy was performed in an attempt to isolate and elucidate the structures of the compounds that were present in the extract. The extract yielded five known compounds of which only two, viz. oleanonic acid and 3-Epioleanolic acid, displayed uterotonic activity. Receptor binding assays were subsequently performed with 3-Epioleanolic acid to ascertain its mode of action. Bradykinin (30 ng/100 microl) and acetylcholine (1 microg/100 microl) were used as the B2 and cholinergic receptor agonists respectively with icatibant (HOE 140) (30 ng/100 microl) and atropine (60 micro/100 microl) as their corresponding antagonists. 3-Epioleanolic acid was observed to mediate its effect through the cholinergic receptor.
Source
Molecular Weight 456.7
Formula C30H48O3
CAS No. 25499-90-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (120.43 mM)

TargetMolReferences and Literature

1. The uterotonic activity of compounds isolated from the supercritical fluid extract of Ekebergia capensis.J Pharm Biomed Anal. 2000 Dec;24(1):133-45.

Related compound libraries

This product is contained In the following compound libraries:
Antiparasitic Natural Product Library Bioactive Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library Human Metabolite Library Terpene Natural Product Library PBCRBS Traditional Chinese Medicine Compound Library Human Endogenous Metabolite Compound Library Plus Bioactive Compounds Library Max Natural Product Library for HTS

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Keywords

3-Epioleanolic acid 25499-90-5 Neuroscience AChR Inhibitor inhibit 3 Epioleanolic acid 3Epioleanolic acid inhibitor

 

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