Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it exhibits greater cytotoxicity compared to PKC412[1].
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Description | 3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it exhibits greater cytotoxicity compared to PKC412[1]. |
Targets&IC50 | FLT3 in plasma:9.8 μM, FLT3 in culture medium:132 nM |
Synonyms | CGP52421 |
Molecular Weight | 586.648 |
Formula | C35H30N4O5 |
CAS No. | 179237-49-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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3-Hydroxy Midostaurin 179237-49-1 Angiogenesis Tyrosine Kinase/Adaptors FLT CGP52421 3Hydroxy Midostaurin CGP 52421 CGP-52421 3 Hydroxy Midostaurin inhibitor inhibit