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4-Hydroxyestrone

Catalog No. T9454 CAS 3131-23-5

4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.

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4-Hydroxyestrone, CAS 3131-23-5

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Description	4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
In vitro	Using immortalized mouse hippocampal neuronal cells as an in vitro model, 4-Hydroxyestrone, an estrone metabolite with little estrogenic activity, is found to have the strongest neuroprotective effect against oxidative neurotoxicity among 25 endogenous estrogen metabolites tested, and its protective effect is stronger than 17β-estradiol. Similarly, 4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats[1].
In vivo	4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats. Neuroprotection by 4-hydroxyestrone involves increased cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. Analysis of brain microsomal enzymes shows that estrogen 4-hydroxylation is the main metabolic pathway in the central nervous system[1].

Molecular Weight	286.37
Formula	C18H22O3
CAS No.	3131-23-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Choi HJ, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283. 2. Camargo MC, et al. Urinary estrogen metabolites and gastric cancer risk among postmenopausal women. Cancer Rep (Hoboken). 2021 Nov 11:e1574.

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Keywords

4-Hydroxyestrone 3131-23-5 Endocrinology/Hormones Metabolism Estrogen Receptor/ERR Endogenous Metabolite Inhibitor neuroprotective Estrone p53 SIRT1 metabolite inhibit estrogenic oxidative neurotoxicity 4-OHE1 4 Hydroxyestrone 4Hydroxyestrone deacetylation inhibitor

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