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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 84.00 | |
50 mg | In stock | $ 126.00 | |
100 mg | In stock | $ 196.00 | |
200 mg | In stock | $ 298.00 | |
500 mg | In stock | $ 496.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 32.00 |
Description | 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties. |
In vitro | At room temperature and in an atmosphere with oxygen, Metamizole is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine [2]. |
In vivo | Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine [1]. |
Molecular Weight | 217.27 |
Formula | C12H15N3O |
CAS No. | 519-98-2 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (225.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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4-Methylamino antipyrine 519-98-2 Immunology/Inflammation Metabolism Neuroscience COX Drug Metabolite analgesic nonopioid Inhibitor anti-inflammatory metabolite antipyretic NSAID Metamizole Cyclooxygenase 4Methylamino antipyrine 4 Methylamino antipyrine inhibit inhibitor