Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 223.00 | |
50 mg | In stock | $ 413.00 | |
100 mg | In stock | $ 618.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | 4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. |
In vitro | In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86[1]. |
In vivo | 4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. |
Synonyms | 4-phenyl-2- propionamidotetralin |
Molecular Weight | 279.38 |
Formula | C19H21NO |
CAS No. | 134865-74-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.67 mg/mL (149.15 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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4-P-PDOT 134865-74-0 GPCR/G Protein Neuroscience Melatonin Receptor MT Receptor Melatonin 4-phenyl-2- propionamidotetralin GSSG Nrf2 GSH 4PPDOT ERK memory damage Inhibitor oxidative 4 P PDOT MT2 inhibit inhibitor