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5'-Fluoroindirubinoxime

Catalog No. T8317 CAS 861214-33-7

Synonyms: 5'-FIO

5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

5'-Fluoroindirubinoxime Chemical Structure

5'-Fluoroindirubinoxime, CAS 861214-33-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 73.00
2 mg	In stock	$ 107.00
5 mg	In stock	$ 172.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 375.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 657.00
1 mL * 10 mM (in DMSO)	In stock	$ 196.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
Targets&IC50	FLT3:15 nM

Synonyms	5'-FIO
Molecular Weight	295.27
Formula	C16H10FN3O2
CAS No.	861214-33-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (282.22 mM), Sonification is recommended.

References and Literature

1. Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9. 2. Choi SJ, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2033-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Lung Cancer Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Angiogenesis related Compound Library Kinase Inhibitor Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

5'-Fluoroindirubinoxime 861214-33-7 Angiogenesis Tyrosine Kinase/Adaptors FLT FLT3 HT-1080 CD135 A549 Cluster of differentiation antigen 135 RK3E-ras SNU-638 Fms like tyrosine kinase 3 5'-FIO Inhibitor 5'Fluoroindirubinoxime inhibit 5' Fluoroindirubinoxime inhibitor

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